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RIRCA
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??????Reproductive Immu?n?ology Res???ea??rch Consortium in Africa (RIRCA)???

Publications

2023

  1. Iwase SC, Edlefsen PT, Bhebhe L, Motsumi K, Moyo S, Happel AU, Shao D, Mmasa N, Schenkel S, Gasper MA, Dubois M, Files MA, Seshadri C, Duffy F, Aitchison J, Netea MG, Jao J, Cameron DW, Gray CM, Jaspan HB, Powis KM. T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure. Clin Infect Dis. 2023 Oct13;77(8):1133-1136. doi: 10.1093/cid/ciad356. PubMed PMID: 37293702;PubMed Central PMCID: PMC10573724.
  2. Rametse CL, Webb EL, Herrera C, Alinde B, Besethi A, Motaung B, Mbangiwa T, Leach L, Sebaa S, Pillay AAP, Seiphetlo TB, Malhangu B, Petkov S, Else L, Mugaba S, Namubiru P, Odoch G, Opoka D, Serwanga J, Ssemata AS, Kaleebu P, Khoo S, Lebina L, Martinson N, Chiodi F, Fox J, Gray CM. A randomized clinical trial of on-demand oral pre-exposure prophylaxis does not modulate lymphoid/myeloid HIV target cell density in the foreskin. AIDS. 2023 Sep 1;37(11):1651-1659. doi: 10.1097/QAD.0000000000003619. Epub 2023 Jun 6.PubMed PMID: 37289572.
  3. Hartmann S, Botha SM, Gray CM, Valdes DS, Tong S, Kaitu'u-Lino TJ, Herse F, Bergman L, Cluver CA, Dechend R, Nonn O. Can single-cell and spatial omics unravel the pathophysiology of pre-eclampsia?. J Reprod Immunol. 2023 Sep;159:104136. doi: 10.1016/j.jri.2023.104136. Epub 2023 Aug 17. Review.PubMed PMID: 37634318.
  4. Gray CM, Borger JG. The immunology ecosystem in South Africa: striking an equitable balance between fostering discovery, promoting translation and capacity building. Immunol Cell Biol. 2023 Jul 31;. doi: 10.1111/imcb.12672.[Epub ahead of print] PubMed PMID: 37524375.
  5. Iwase SC, Jaspan HB, Happel AU, Holmes SP, Abimiku A, Osawe S, Gray CM, Blackburn JM. Longitudinal gut microbiota composition of South African and Nigerian infants in relation to tetanus vaccine responses. Res Sq. 2023 Jul 3;.doi: 10.21203/rs.3.rs-3112263/v1. PubMed PMID: 37461449; PubMed Central PMCID: PMC10350179.
  6. Herrera C, Serwanga J, Else L, Limakatso L, Opoka D, Ssemata AS, Pillay AD, Namubiru P, Seiphetlo TB, Odoch G, Mugaba S, Seatlholo P, Alieu A, Penchala SD, Muhumuza R, Alinde B, Petkov S, O'Hagan K, Callebaut C, Seeley J, Weiss H, Khoo S, Chiodi F, Gray CM, Kaleebu P, Webb EL, Martinson N, Fox J. Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trial. EBioMedicine. 2023 Jul;93:104648. doi: 10.1016/j.ebiom.2023.104648. Epub 2023 Jun 14. PubMed PMID: 37327677; PubMed Central PMCID:PMC10275696.
  7. Dzanibe S, Wilk AJ, Canny S, Ranganath T, Alinde B, Rubelt F, Huang H, Davis MM, Holmes S, Jaspan HB, Blish CA, Gray CM. Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality. bioRxiv. 2023 May 24;. doi:10.1101/2023.05.19.540713. PubMed PMID: 37292866; PubMed Central PMCID: PMC10245741.
  8. Ikumi NM, Koenig Z, Mahajan S, Gray CM, Tilburgs T. Purification of primary human placental leukocytes to study maternal-fetal interactions. STAR Protoc. 2023 May 12;4(2):102277. doi: 10.1016/j.xpro.2023.102277. [Epub ahead of print] PubMed PMID: 37182206; PubMed Central PMCID: PMC10199256.
  9. Cardenas MC, Farnan S, Hamel BL, Mejia Plazas MC, Sintim-Aboagye E, Littlefield DR, Behl S, Punia S, Enninga EAL, Johnson E, Temesgen Z, Theiler R, Gray CM, Chakraborty R. Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far. Viruses. 2023 Mar 26;15(4). doi:10.3390/v15040849. Review. PubMed PMID: 37112830; PubMed Central PMCID: PMC10142818.

2022

  1. Petkov S, Herrera C, Else L, Lebina L, Opoka D, Seiphetlo TB, Pillay AA, Mugaba S, Namubiru P, Odoch G, Ssemata AS, Serwanga J, Kaleebu P, Webb EL, Khoo S, Martinson N, Gray CM, Fox J, Chiodi F. Short-term oral preexposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa. Front Immunol. 2022;13: 1009978. doi:10.3389/fimmu.2022.1009978. eCollection 2022. PubMed PMID: 36479111;PubMed Central PMCID: PMC9720390.
  2. Chigorimbo-Murefu NTL, Potgieter M, Dzanibe S, Gabazana Z, Buri G, Chawla A, Nleya B, Olivier AJ, Harryparsad R, Calder B, Garnett S, Maziya L, Lewis DA, Jaspan H, Wilson D, Passmore J-AS, Mulder N, Blackburn J, Bekker L-G and Gray CM. A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome. Front. Microbiol. 2022, 13:928317. doi:10.3389/fmicb.2022.928317
  3. Petkov S, Herrera C, Else L, Mugaba S, Namubiru P, Odoch G, Opoka D, Pillay AAP, Seiphetlo TB, Serwanga J, Ssemata AS, Kaleebu P, Webb EL, Khoo S, Lebina L, Gray CM, Martinson N, Fox J, Chiodi F. Mobilization of systemic CCL4 following HIV pre-exposure prophylaxis in young men in Africa. Front Immunol.2022;13:965214. doi: 10.3389/fimmu.2022.965214. eCollection 2022. PubMedPMID: 35967369; PubMed Central PMCID: PMC9363563.
  4. Balle C, Armistead B, Kiravu A, Song X, Happel AU, Hoffmann AA, Kanaan SB, Nelson JL, Gray CM, Jaspan HB, Harrington WE. Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity. J Clin Invest. 2022 Jul 1;132(13). doi: 10.1172/JCI148826. PubMed PMID: 35550376; PubMed Central PMCID: PMC9246390.
  5. Norris SA, Draper CE, Prioreschi A, Smuts CM, Ware LJ, Dennis C, Awadalla P, Bassani D, Bhutta Z, Briollais L, Cameron DW, Chirwa T, Fallon B, Gray CM, Hamilton J, Jamison J, Jaspan H, Jenkins J, Kahn K, Kengne AP, Lambert EV, Levitt N, Martin MC, Ramsay M, Roth D, Scherer S, Sellen D, Slemming W, Sloboda D, Szyf M, Tollman S, Tomlinson M, Tough S, Matthews SG, Richter L, Lye S. Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI). BMJ Open. 2022 Apr 21;12(4): e059914. doi: 10.1136/bmjopen-2021-059914. PubMed PMID: 35450913; PubMed Central PMCID: PMC9024255.


2021

  1. Dzanibe S, Lennard K, Kiravu A, Seabrook MSS, Alinde B, Holmes SP, Blish CA, Jaspan HB, Gray CM. Stereotypic Expansion of T Regulatory and Th17 Cells during Infancy Is Disrupted by HIV Exposure and Gut Epithelial Damage. J Immunol. 2022 Jan 1;208(1):27-37. doi: 10.4049/jimmunol.2100503. Epub 2021 Nov 24. PubMed PMID: 34819390; PubMed Central PMCID: PMC8702481.
  2. Ikumi NM, Matjila M, Gray CM, Anumba D, Pillay K. Placental pathology in women with HIV. Placenta. 2021 Sep 11;115:27-36. doi: 10.1016/j.placenta.2021.09.006. Online ahead of print. PMID: 34537469
  3. Lunjani N, Tan G, Dreher A, Sokolowska M, Groeger D, Warwyzniak M, Altunbulakli C, Westermann P, Basera W, Hobane L, Botha M, Gray C, Mankahla A, Gray C, Nadeau KC, Hlela C, Levin M, O'Mahony L, Akdis CA. Environment-dependent alterations of immune mediators in urban and rural South African children with atopic dermatitis. Allergy. 2022 Feb;77(2):569-581. doi: 10.1111/all.14974. Epub 2021 Jun 15. PubMed PMID: 34086351.
  4. Davies J, Vallejo AF, Sirvent S, Porter G, Clayton K, Qumbelo Y, Stumpf P, West J, Gray CM, Chigorimbo-Murefu NTL, MacArthur B, Polak ME. An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells. Front Immunol. 2021;12:665312. doi: 10.3389/fimmu.2021.665312. eCollection 2021. PubMed PMID: 34211464; PubMed Central PMCID: PMC8239435.
  5. Peng K, Safonova Y, Shugay M, Popejoy AB, Rodriguez OL, Breden F, Brodin P, Burkhardt AM, Bustamante C, Cao-Lormeau VM, Corcoran MM, Duffy D, Fuentes-Guajardo M, Fujita R, Greiff V, J?nsson VD, Liu X, Quintana-Murci L, Rossetti M, Xie J, Yaari G, Zhang W, Abedalthagafi MS, Adekoya KO, Ahmed RA, Chang WC, Gray C, Nakamura Y, Lees WD, Khatri P, Alachkar H, Scheepers C, Watson CT, Karlsson Hedestam GB, Mangul S. Diversity in immunogenomics: the value and the challenge. Nat Methods. 2021 May 17;. doi: 10.1038/s41592-021-01169-5
  6. Christina Balle, Agano Kiravu, Angela Hoffmann, Anna-Ursula Happel, Sami B. Kanaan, J Lee Nelson, Clive M Gray, Heather B Jaspan, Whitney E Harrington. Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity. bioRxiv 2021.03.02.432825; doi: https://doi.org/10.1101/2021.03.02.432825
  7. Mdletshe N, Thobakgale C, Malaba TR, Madlala H, Myer L, Muema DM, Mogeni P, Gray CM, Altfeld M, Newell ML, Ndung'u T. Low immune activation in early pregnancy is associated with preterm but not small-for-gestational age delivery in HIV infected women initiating antiretroviral therapy in pregnancy: a PIMS casecontrol study in Cape Town, South Africa. Clin Infect Dis. 2021 Feb 19;. doi:10.1093/cid/ciab151. [Epub ahead of print] PubMed PMID: 33606024.
  8. Ikumi NM, Pillay K, Tilburgs T, Malaba TR, Dzanibe S, Enninga EAL, Chakraborty R, Lamorde M, Myer L, Khoo S, Jaspan HB, Gray CM. T-Cell Homeostatic Imbalance in Placentas From Women With Human Immunodeficiency Virus in the Absence of Vertical Transmission. J Infect Dis. 2021 Dec 8;224(12 Suppl 2):S670-S682. doi: 10.1093/infdis/jiab192. PubMed PMID: 33880544.

 

2020

  1. Nash S, Dietrich J, Ssemata AS, Herrera C, O'Hagan K, Else L, Chiodi F, Kelly C, Shattock R, Chirenje M, Lebina L, Khoo S, Bekker LG, Weiss HA, Gray C, Stranix-Chibanda L, Kaleebu P, Seeley J, Martinson N, Fox J. Combined HIV Adolescent Prevention Study (CHAPS): comparison of HIV pre-exposure prophylaxis regimens for adolescents in sub-Saharan Africa-study protocol for a mixed methods study including a randomised controlled trial. Trials. 2020 Oct 30;21(1):900. doi: 10.1186/s13063-020-04760-x. PubMed PMID: 33121503; PubMed Central PMCID: PMC7596950.
  2. Malaba TR, Myer L, Gray C, Newell ML. Cohort profile: Prematurity Immunology in Mothers living with HIV and their infants Study (PIMS). BMJ Open. 2021 Sep 30;11(9):e047133. doi: 10.1136/bmjopen-2020-047133. PubMed PMID: 34593488; PubMed Central PMCID: PMC8487191
  3. Ikumi NM, Malaba TR, Pillay K, Cohen MC, Madlala HP, Matjila M, Anumba D, Myer L, Newell ML, Gray CM. Differential impact of antiretroviral therapy initiated before or during pregnancy on placenta pathology in HIV-positive women. AIDS. 2021;35(5):717-726. doi: 10.1097/QAD.0000000000002824. PubMed PMID: 33724257.
  4. Osier FHA, Mwandumba HC, Gray CM. Turning Discoveries into Treatments: Immunology in Africa. Trends Immunol. 2020 Dec;41(12):1051-1053. doi: 10.1016/j.it.2020.10.007. Epub 2020 Nov 4. Review. PubMed PMID: 33160840.
  5. Valley-Omar Z, Maart S, Seele K, Gray CM. Characterization of the novel HLADQB1*05:272 allele in a South African patient by next-generation sequencing.HLA. 2021 Feb;97(2):173-174. doi: 10.1111/tan.14143. Epub 2020 Nov 25.PubMed PMID: 33219591.
  6. Chukwudozie OS, Gray CM, Fagbayi TA, Chukwuanukwu RC, Oyebanji VO, Bankole TT, Adewole RA, Daniel EM. Immuno-informatics design of a multimeric epitope peptide based vaccine targeting SARS-CoV-2 spike glycoprotein. PLoS One. 2021;16(3):e0248061. doi: 10.1371/journal.pone.0248061. eCollection 2021. PubMed PMID: 33730022.
  7. Gray CM, Peter J, Mendelson M, Madhi SA, Blackburn JM. COVID-19 antibody testing: From hype to immunological reality. South African Medical Journal. Published online 27 July 2020. https://doi.org/10.7196/SAMJ.2020.v110i9.15155
  8. Enninga EAL, Raber P, Quinton RA, Ruano R, Ikumi N, Gray CM, Johnson EL, Chakraborty R, Kerr SE. Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis. J Immunol. 2020 Apr 22;. doi: 10.4049/jimmunol.1901297. [Epub ahead of print] PubMed PMID: 32321754.
  9. Chambuso R, Ramesar R, Kaambo E, Murahwa AT, Abdallah MOE, De Sousa M, Denny L, Williamson AL, Gray CM. Age, absolute CD4 count, and CD4 percentage in relation to HPV infection and the stage of cervical disease in HIV-1-positive women. Medicine 2020 Feb;99(9):e19273. doi: 10.1097/MD.0000000000019273.PMID: 32118737

2019

  1. Gray CM, O'Hagan KL, Lorenzo-Redondo R, Olivier AJ, Amu S, Chigorimbo- Murefu N, Harryparsad R, Sebaa S, Maziya L, Dietrich J, Otwombe K, Martinson N, Ferrian S, Mkhize NN, Lewis DA, Lang D, Carias AM, Jaspan HB, Wilson DPK, McGilvray M, Cianci GC, Anderson MR, Dinh MH, Williamson AL, Passmore JS, Chiodi F, Hope TJ. Impact of chemokine C-C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males. Mucosal Immunol. 2019 Oct 16;. doi: 10.1038/s41385-019-0209-6. PubMed PMID: 31619762.
  2. Kiravu A, Osawe S, Happel AU, Nundalall T, Wendoh J, Beer S, Dontsa N, Alinde OB, Mohammed S, Datong P, Cameron DW, Rosenthal K, Abimiku A, Jaspan HB, Gray CM. Bacille Calmette-Guérin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants. Front Immunol. 2019;10:2307. doi: 10.3389/fimmu.2019.02307. eCollection 2019. PubMed PMID: 31649662; PubMed Central PMCID: PMC6793433.
  3. Chambuso R, Kaambo E, Denny L, Gray CM, Williamson AL, Migdalska-S?k M, Agenbag G, Rebello G, Ramesar R. Investigation of Cervical Tumor Biopsies for Chromosomal Loss of Heterozygosity (LOH) and Microsatellite Instability (MSI) at the HLA II Locus in HIV-1/HPV Co-infected Women. Front Oncol. 2019;9:951. doi: 10.3389/fonc.2019.00951. eCollection 2019. PubMed PMID: 31681558; PubMed Central PMCID: PMC6803484.
  4. Kabelitz D, Letarte M, Gray CM. Immunology Education Without Borders. Front Immunol. 2019;10:2012. doi: 10.3389/fimmu.2019.02012. eCollection 2019. PubMed PMID: 31555265; PubMed Central PMCID: PMC6724660.
  5. Mellet J, Tshabalala M, Agbedare O, Meyer P, Gray CM, Pepper MS. Human leukocyte antigen (HLA) diversity and clinical applications in South Africa. S Afr Med J. 2019 Sep 10;109(8b):29-34. doi: 10.7196/SAMJ.2019.v109i8b.13825. PubMed PMID: 31662146.
  6. Chambuso R, Ramesar R, Kaambo E, Denny L, Passmore JA, Williamson AL, Gray CM. Human Leukocyte Antigen (HLA) Class II -DRB1 and -DQB1 Alleles and the Association with Cervical Cancer in HIV/HPV Co-Infected Women in South Africa. J Cancer. 2019;10(10):2145-2152. doi: 10.7150/jca.25600. eCollection 2019. PubMed PMID: 31258717; PubMed Central PMCID: PMC6584421
  7. Zulu MZ, Martinez FO, Gordon S, Gray CM. The Elusive role of Placental Macrophages: The Hofbauer Cell. J Innate Immun. 2019 Apr 10:1-10. doi: 10.1159/000497416.

 

2018

  1. Chambuso R, Gray CM, Kaambo E, Rebello G, Ramesar R. Impact of Host Molecular Genetic Variations and HIV/HPV Co-infection on Cervical Cancer Progression: A Systematic review. Oncomedicine 2018; 3:82-93. doi:10.7150/oncm.25573. Available from http://www.oncm.org/v03p0082.htm
  2. Dzanibe S, Jaspan HB, Zulu MZ, Kiravu A, Gray CM. Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity. J Leukoc Biol. 2019 Feb;105(2):281-289. doi: 10.1002/JLB.MR0318-120R. Epub 2018 Dec 21. Review. PubMed PMID: 30577072.
  3. Ferrian S, Ross M, Conradie F, Vally Omar S, Ismail N, Little F, Kaplan G, Fallows G and Gray CM. Frequency of Circulating CD4+Ki67+HLA-DR? T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion. Front. Immunol. 2018; https://doi.org/10.3389/fimmu.2018.02438
  4. Malaba TR, Newell ML, Madlala H, Perez A, Gray C, Myer L. Methods ofgestational age assessment influence the observed association between antiretroviral therapy exposure, preterm delivery, and small-for-gestational age infants: a prospective study in Cape Town, South Africa. Ann Epidemiol. 2018 Aug29. pii: S1047-2797(18)30329-6. doi: 10.1016/j.annepidem.
  5. Tchakoute CT, Sainani KL, Osawe S, Datong P, Kiravu A, Rosenthal KL, Gray CM,Cameron DW, Abimiku A, Jaspan HB; INFANT study team. Breastfeeding mitigates the effects of maternal HIV on infant infectious morbidity in the Option B+ era: A multicenter prospective cohort study. AIDS. 2018 Aug 20. doi:10.1097/QAD.0000000000001974
  6. Barnabas SL, Dabee S, Passmore JS, Jaspan HB, Lewis DA, Jaumdally SZ, Gamieldien H, Masson L, Muller E, Maseko VD, Mkhize N, Mbulawa Z, Williamson AL, Gray CM, Hope TJ, Chiodi F, Dietrich J, Gray G, Bekker LG. Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV. Women's Initiative in Sexual Health (WISH) study team. Int J STD AIDS. 2018 May;29(6):531-539. doi:10.1177/0956462417740487. Epub 2017 Dec 4. ??