Division of Molecular Biology & Human Genetics
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?Tuberculosis Host Genetics
?Research
Gene-Gene Interactions
?Increasing
evidence show that host genetic factors determine susceptibility to
developing disease. These factors are complex, and examining them in
isolation may result in missing the effect of factors that do not act
independently, i.e. when the effect of one gene on disease outcome is
modified by the variant of another gene.
It is therefore important to understand the role of gene-gene interactions, commonly referred to as epistasis, in susceptibility to tuberculosis infection.
The statistical tools and methods we use to find interactions in our large tuberculosis case-control sample bank are also relevant to other complex diseases with multiple underlying genetic causes.
