????Division of Molecular Biology & Human Genetics

 

?Mycobacteriology: ?Host-Pathogen Mycobactomics?HPM_Logo_2021.png

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Research overview


The overall research goal of the Stellenbosch 肆客足球 Host-Pathogen Mycobactomics group is to gain a better understanding of how the pathogen Mycobacterium tuberculosis interacts with its host to cause disease. To achieve this, we use molecular mycobacteriology and infection models together with data-rich "omics" methodologies such as whole genome sequencing, transcriptomics, proteom?ics and cytomics. These methods are underpinned by computational approaches. Specific research areas include: (a) advancing our understanding of TB host-pathogen interactions, with a particular focus on persistent  mycobacteria, (b) elucidating the biology PE/PPE proteins of M. tuberculosis, and (c) developing new host-directed nanoparticle therapies for TB.